RESUMO
ABSTRACT Neuroleptic malignant syndrome (NMS) is a neurologic emergency potentially fatal. This rare side effect is most commonly associated with first-generation antipsychotics and less frequently with atypical or second-generation antipsychotics. The diagnosis relies on both clinical and laboratory criteria, with other organic and psychiatric conditions being ruled out. CASE REPORT: A 39-year-old female patient, who is institutionalized and completely dependent, has a medical history of recurrent urinary infections and colonization by carbapenem-resistant Klebsiella pneumoniae. Her regular medication regimen included sertraline, valproic acid, quetiapine, risperidone, lorazepam, diazepam, haloperidol, baclofen, and fentanyl. The patient began experiencing dyspnea. Upon physical examination, she exhibited hypotension and a diminished vesicular murmur at the right base during pulmonary auscultation. Initially, after hospitalization, she developed high febrile peaks associated with hemodynamic instability, prompting the initiation of antibiotic treatment. Despite this, her fever persisted without an increase in blood inflammatory parameters, and she developed purulent sputum, necessitating antibiotherapy escalation. The seventh day of hospitalization showed no improvement in symptoms, suggesting NNMS as a differential diagnosis. All antipsychotic and sedative drugs, as well as antibiotherapy, were discontinued, after which the patient showed significant clinical improvement. CONCLUSION: Antipsychotic agents are commonly employed to manage behavioral changes linked to various disorders. However, their severe side effects necessitate a high degree of vigilance, the cessation of all medications, and the implementation of supportive care measures. A prompt and accurate diagnosis of NMS is crucial to alleviating the severe, prolonged morbidity and potential mortality associated with this syndrome.
RESUMO
Este trabalho de revisão de literatura pretende demonstrar não só a importância da introdução da disciplina de Informática Odontológica no currículo das Faculdades de Odontologia mas também no cotidiano do médico-dentista ou cirurgião-dentista. Nos últimos anos houve um rápido desenvolvimento da Informática aplicada à Odontologia, sobretudo em áreas dedicadas ao exame do paciente, ao diagnóstico e ao plano de tratamento. Os sistemas CAD-CAM, as sondas periodontais computadorizadas, os aparelhos de radiologia digital, as câmaras intra-orais são exemplos da aplicação da Informática em Odontologia. É neste sentido que surge a disciplina de Informática Odontológica, uma área em constante desenvolvimento, que tem por base a aplicação de computadores e ciências de informação para melhorar a prática clínica, a pesquisa, a educação e a gestão. É importante que simultaneamente com a formação em Odontologia haja também adequada formação em Informática Odontológica. Atualmente os avanços tecnológicos e as pesquisas científicas requerem interdisciplinaridade e integração de uma grande quantidade de informação, muitas vezes proveniente de fontes díspares, havendo necessidade de compilar a informação em bases de dados. Os meios informáticos podem aumentar significativamente a velocidade de integração e correlação dessa informação, tornando o diagnóstico médico-odontológico mais rápido e a implementação da terapêutica mais eficaz.
This literature review aimed to present the importance of the discipline of Dental Informatics for the curriculum of dental schools and daily dental practice. In the last years there was a fast development of Informatics applied to Dentistry, especially in areas related to patient exam, diagnosis, and treatment plan. CAD-CAM systems, computerized periodontal probes, digital radiography, and intraoral cameras are examples of the application of Informatics in Dentistry. Dental Informatics is a discipline showing constant development and is based on the application of computers and information science to improve clinical practice, research, education, and management. Therefore, it is important that Dental Informatics is included in the dental curriculum. At present the technological advances and scientific research require interdisciplinary approach and integration of large amount of information. This information usually comes from several sources, which requires its compilation in databases. Informatics media can significantly increase the velocity of integration and correlation of necessary information to speed up the medical-dental diagnosis and improve treatment efficacy.